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PART ONE — INTRODUCTION TO CLINICAL MEDICINE

1. The Practice of Medicine — The Editors
2. Decision-Making in Clinical Medicine — Daniel B. Mark
3. Principles of Clinical Pharmacology — Dan M. Roden
4. Screening and Prevention of Disease — Gary J. Martin
5. Women's Health — Andrea Dunaif
6. Medical Disorders During Pregnancy — Robert L. Barbieri/ John T. Repke
7. Medical Evaluation of the Surgical Patient — Gerald W. Smetana
8. Geriatric Medicine — Neil M. Resnick / David Dosa
9. Palliative and End-of-Life Care — Ezekiel J. Emanuel / Linda L. Emanuel
10. Complementary and Alternative Medicine — Stephen E. Straus

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PART TWO — CARDINAL MANIFESTATIONS AND PRESENTATION OF DISEASES

Section 1: Pain
11. Pain: Pathophysiology and Management — Howard L. Fields / Joseph B. Martin
12. Chest Discomfort and Palpitations — Thomas H. Lee
13. Abdominal Pain — William Silen
14. Headache — Neil H. Raskin
15. Back and Neck Pain — John W. Engstrom

Section 2: Alterations in Body Temperature
16. Fever and Hyperthermia — Charles A. Dinarello / Jeffrey A. Gelfand
17. Fever and Rash — Elaine T. Kaye / Kenneth M. Kaye
18. Fever of Unknown Origin — Jeffrey A. Gelfand / Michael V. Callahan
19. Hypothermia and Frostbite — Daniel F. Danzl

Section 3: Nervous System Dysfunction
20. Syncope, Faintness, Dizziness, and Vertigo — Robert B. Daroff / Mark D. Carlson
21. Weakness, Disorders of Movement, and Imbalance — Richard K. Olney
22. Numbness, Tingling, and Sensory Loss — Arthur K. Asbury
23. Aphasia, Memory Loss, and Other Focal Cerebral Disorders — M-Marsel Mesulam
24. Sleep Disorders — Charles A. Czeisler / John W. Winkelman / Gary S. Richardson

Section 4: Disorders of Eyes, Ears, Nose, and Throat
25. Disorders of the Eye — Jonathan C. Horton
26. Disorders of Smell, Taste, and Hearing — Anil K. Lalwani / James B. Snow, Jr.
27. Infections of the Upper Respiratory Tract — Michael A. Rubin / Ralph Gonzales / Merle A. Sande
28. Oral Manifestations of Disease — Samuel C. Durso

Section 5: Alterations in Circulatory and Respiratory Functions
29. Dyspnea and Pulmonary Edema — Roland H. Ingram, Jr. / Eugene Braunwald
30. Cough and Hemoptysis — Steven E. Weinberger
31. Hypoxia and Cyanosis — Eugene Braunwald
32. Edema — Eugene Braunwald

Section 6: Alterations in Gastrointestinal Function
33. Dysphagia — Raj K. Goyal
34. Nausea, Vomiting, and Indigestion — William L. Hasler
35. Diarrhea and Constipation — David A. Ahlquist / Michael Camilleri
36. Weight Loss — Carol M. Reife
37. Gastrointestinal Bleeding — Loren Laine
38. Jaundice — Daniel S. Pratt / Marshall M. Kaplan
39. Abdominal Swelling and Ascites — Robert M. Glickman

Section 7: Alterations in Renal and Urinary Tract Function
40. Azotemia and Urinary Abnormalities — Bradley M. Denker / Barry M. Brenner
41. Fluid and Electrolyte Disturbances — Gary G. Singer / Barry M. Brenner
42. Acidosis and Alkalosis — Thomas D. DuBose, Jr.

Section 8: Alterations in Sexual Function and Reproduction
43. Sexual Dysfunction — Kevin T. McVary
44. Hirsutism and Virilization — David A. Ehrmann
45. Infertility and Fertility Control — Janet E. Hall

Section 9: Alterations in the Skin
46. Approach to the Patient with a Skin Disorder — Thomas J. Lawley / Kim B. Yancey
47. Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders — Calvin O. McCall / Thomas J. Lawley
48. Skin Manifestations of Internal Disease — Jean L. Bolognia / Irwin M. Braverman
49. Immunologically Mediated Skin Diseases — Kim B. Yancey / Thomas J. Lawley
50. Cutaneous Drug Reactions — Olivier M. Chosidow / Robert S. Stern/ Bruce U. Wintroub
51. Photosensitivity and Other Reactions to Light — David R. Bickers

Section 10: Hematologic Alterations
52. Anemia and Polycythemia — John W. Adamson / Dan L. Longo
53. Bleeding and Thrombosis — Robert I. Handin
54. Enlargement of Lymph Nodes and Spleen — Patrick H. Henry / Dan L. Longo
55. Disorders of Granulocytes and Monocytes — Steven M. Holland / John I. Gallin

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PART THREE — GENETICS AND DISEASE

56. Principles of Human Genetics — J. Larry Jameson / Peter Kopp
57. Chromosome Disorders — Terry Hassold / Stuart Schwartz
58. The Practice of Genetics in Clinical Medicine — Susan Miesfeldt / J. Larry Jameson
59. Stem Cell and Gene Transfer in Clinical Medicine — David Bodine / J. Larry Jameson / Ron McKay

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PART FOUR — NUTRITION

60. Nutritional Requirements and Dietary Assessment — Johanna Dwyer
61. Vitamin and Trace Mineral Deficiency and Excess — Robert M. Russell
62. Malnutrition and Nutritional Assessment — Charles H. Halsted
63. Enteral and Parenteral Nutrition Therapy — Lyn Howard
64. Obesity — Jeffrey S. Flier / Eleftheria Maratos-Flier
65. Eating Disorders — B. Timothy Walsh

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PART FIVE — ONCOLOGY AND HEMATOLOGY

Section 1: Neoplastic Disorders
66. Approach to the Patient with Cancer — Dan L. Longo
67. Prevention and Early Detection of Cancer — Otis W. Brawley / Barnett S. Kramer
68. Cancer Genetics — Patrice J. Morin / Jeffrey M. Trent / Francis S. Collins / Bert Vogelstein
69. Cancer Biology and Angiogenesis — Robert G. Fenton / Dan L. Longo
70. Principles of Cancer Treatment: Surgery, Chemotherapy, and Biologic Therapy — Edward A. Sausville / Dan L. Longo
71. Principles of Radiation Therapy — Stephen M. Hahn / Eli Glatstein
72. Infections in Patients with Cancer — Robert Finberg
73. Cancer of the Skin — Katarina G. Chiller / Carl Washington / Arthur J. Sober / Howard K. Koh
74. Head and Neck Cancer — Everett E. Vokes
75. Neoplasms of the Lung — John D. Minna
76. Breast Cancer — Marc E. Lippman
77. Gastrointestinal Tract Cancer — Robert J. Mayer
78. Tumors of the Liver and Biliary Tract — Jules L. Dienstag / Kurt J. Isselbacher
79. Pancreatic Cancer — Robert J. Mayer
80. Bladder and Renal Cell Carcinomas — Howard I. Scher / Robert J. Motzer
81. Hyperplastic and Malignant Diseases of the Prostate — Howard I. Scher
82. Testicular Cancer — Robert J. Motzer / George J. Bosl
83. Gynecologic Malignancies — Robert C. Young
84. Soft Tissue and Bone Sarcomas and Bone Metastases — Shreyaskumar R. Patel / Robert S. Benjamin
85. Metastatic Cancer of Unknown Primary Site — Richard M. Stone
86. Paraneoplastic Syndromes: Endocrinologic/Hematologic — J. Larry Jameson / Bruce E. Johnson
87. Paraneoplastic Neurologic Syndromes — Josep Dalmau / Myrna R. Rosenfeld
88. Oncologic Emergencies — Rasim Gucalp / Janice Dutcher
89. Late Consequences of Cancer and Its Treatment — Michael C. Perry / Dan L. Longo

Section 2: Hematopoietic Disorders
90. Iron Deficiency and Other Hypoproliferative — John W. Adamson
91. Anemias Hemoglobinopathies — Edward J. Benz
92. Megaloblastic Anemias — Bernard M. Babior / H. Franklin Bunn
93. Hemolytic Anemias and Acute Blood Loss — H. Franklin Bunn / Wendell Rosse
94. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes — Neal S. Young
95. Polycythemia Vera and Other Myeloproliferative Diseases — Jerry L. Spivak
96. Acute and Chronic Myeloid Leukemia — Meir Wetzler / John C. Byrd / Clara D. Bloomfield
97. Malignancies of Lymphoid Cells — James O. Armitage / Dan L. Longo
98. Plasma Cell Disorders — Dan L. Longo / Kenneth C. Anderson
99. Transfusion Biology and Therapy — Jeffery S. Dzieczkowski / Kenneth C. Anderson
100. Hematopoietic Cell Transplantation — Frederick R. Appelbaum

Section 3: Disorders of Hemostasis
101. Disorders of the Platelet and Vessel Wall — Robert I. Handin
102. Disorders of Coagulation and Thrombosis — Robert I. Handin
103. Antiplatelet, Anticoagulant, and Fibrinolytic Therapy — Steven R. Deitcher

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PART SIX — INFECTIOUS DISEASES

Section 1: Basic Considerations in Infectious Diseases
104. Introduction to Infectious Diseases: Host-Pathogen Interactions — Lawrence C. Madoff / Dennis L. Kasper
105. Molecular Mechanisms of Microbial Pathogenesis — Gerald B. Pier
106. Approach to the Acutely Ill Infected Febrile Patient — Tamar F. Barlam / Dennis L. Kasper
107. Immunization Principles and Vaccine Use — Gerald T. Keusch / Kenneth J. Bart / Mark Miller
108. Health Advice for International Travel — J.S. Keystone / P.E. Kozarsky

Section 2: Clinical Syndromes: Community-Acquired Infections
109. Infective Endocarditis — Adolf W. Karchmer
110. Infections of the Skin, Muscle, and Soft Tissues — Dennis L. Stevens
111. Osteomyelitis — Jeffrey Parsonnet / James H. Maguire
112. Intraabdominal Infections and Abscesses — Dennis L. Kasper / Dori F. Zaleznik
113. Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning — Joan R. Butterton / Stephen B. Calderwood
114. Clostridium difficile - Associated Disease, Including Pseudomembranous Colitis — Dale N. Gerding / Stuart Johnson
115. Sexually Transmitted Diseases: Overview and Clinical Approach — King K. Holmes

Section 3: Clinical Syndromes: Nosocomial Infections
116. Hospital-Acquired Infections — Robert A. Weinstein
117. Infections in Transplant Recipients — Robert Finberg / Joyce Fingeroth

Section 4: Approach to Therapy for Bacterial Diseases
118. Treatment and Prophylaxis of Bacterial Infections — Gordon L. Archer / Ronald E. Polk

Section 5: Diseases Caused by Gram-Positive Bacteria
119. Pneumococcal Infections — Daniel M. Musher
120. Staphylococcal Infections — Franklin D. Lowy
121. Streptococcal and Enterococcal Infections — Michael R. Wessels
122. Diphtheria and Other Corynebacterial Infections — Randall K. Holmes
123. Infections Caused by Listeria monocytogenes — Anne Schuchat / Claire V. Broome
124. Tetanus — Elias Abrutyn
125. Botulism — Elias Abrutyn
126. Gas Gangrene and Other Clostridial Infections — Dennis L. Kasper / Lawrence C. Madoff

Section 6: Diseases Caused by Gram-Negative Bacteria
127. Meningococcal Infections — David Stephens / Robert S. Munford / Lee M. Wetzler
128. Gonococcal Infections — Sanjay Ram / Peter A. Rice
129. Moraxella catarrhalis and Other Moraxella Species — Daniel M. Musher
130. Haemophilus Infections — Timothy F. Murphy
131. Infections due to the HACEK Group and Miscellaneous Gram-Negative Bacteria — Dennis L. Kasper / Tamar F. Barlam
132. Legionella Infection — Feng-Yee Chang / Victor L. Yu
133. Pertussis and Other Bordetella Infections — Scott A. Halperin
134. Diseases Caused by Gram-Negative Enteric Bacilli — Thomas A. Russo
135. Helicobacter pylori Infections — John C. Atherton / Martin J. Blaser
136. Infections Due to Pseudomonas Species and Related Organisms — Christopher A. Ohl / Matthew Pollack
137. Salmonellosis — Cammie F. Lesser / Samuel I. Miller
138. Shigellosis — Gerald T. Keusch / Dennis J. Kopecko
139. Infections Due to Campylobacter and Related Species — Martin J. Blaser
140. Cholera and Other Vibrioses — Matthew K. Waldor / Gerald T. Keusch
141. Brucellosis — Michael J. Corbel / Nicholas J. Beeching
142. Tularemia — Richard F. Jacobs
143. Plague and Other Yersinia Infections — David T. Dennis / Grant L. Campbell
144. Bartonella Infections, Including Cat-Scratch Disease — Lucy Stuart Tompkins
145. Donovanosis — Gavin Hart

Section 7: Miscellaneous Bacterial Infections
146. Nocardiosis — Gregory A. Filice
147. Actinomycosis — Thomas A. Russo
148. Infections due to Mixed Anaerobic Organisms — Dennis L. Kasper

Section 8: Mycobacterial Diseases
149. Antimycobacterial Agents — Richard J. Wallace, Jr. / Donald E. Griffin
150. Tuberculosis — Mario C. Raviglione / Richard J. O'Brien
151. Leprosy (Hansen's Disease) — Robert H. Gelber
152. Nontuberculous Mycobacteria — C. Fordham von Reyn

Section 9: Spirochetal Diseases
153. Syphilis — Sheila A. Lukehart
154. Endemic Treponematoses — Sheila A. Lukehart
155. Leptospirosis — Peter Speelman
156. Relapsing Fever — David T. Dennis / Edward B. Hayes
157. Lyme Borreliosis — Allen C. Steere

Section 10: Diseases Caused by Rickettsia, Mycoplasma, and Chlamydia
158. Rickettsial Diseases — David Walker / Didier Raoult / J. Stephen Dumler / Thomas Marrie
159. Infections Due to Mycoplasmas — William M. McCormack
160. Chlamydial Infections — Walter E. Stamm

Section 11: Viral Diseases: General Considerations
161. Medical Virology — Fred Wang / Elliott Kieff
162. Antiviral Chemotherapy, Excluding Antiretroviral Drugs — Lindsey R. Baden / Raphael Dolin

Section 12: Infections Due to DNA Viruses
163. Herpes Simplex Viruses — Lawrence Corey
164. Varicella-Zoster Virus Infections — Richard J. Whitley
165. Epstein-Barr Virus Infections, Including Infectious Mononucleosis — Jeffrey I. Cohen
166. Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8 — Martin S. Hirsch
167. Molluscum contagiosum and Other Poxviruses, Excluding Smallpox Virus — Fred Wang
168. Parvovirus — Neil R. Blacklow
169. Human Papillomavirus Infections — Richard C. Reichman

Section 13: Infections Due to DNA and RNA Respiratory Viruses
170. Common Viral Respiratory Infections & Severe Acute Respiratory Syndrome — Raphael Dolin
171. Influenza — Raphael Dolin

Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
172. The Human Retroviruses — Dan L. Longo / Anthony S. Fauci
173. Human Immunodeficiency Disease: AIDS and Related Disorders — Anthony S. Fauci / H. Clifford Lane

Section 15: Infections Due to RNA Viruses
174. Viral Gastroenteritis — Umesh D. Parashar / Roger I. Glass
175. Enteroviruses and Reoviruses — Jeffrey I. Cohen
176. Measles (Rubeola) — Anne Gershon
177. Rubella (German Measles) — Anne Gershon
178. Mumps — Anne Gershon
179. Rabies Virus and Other Rhabdoviruses — Cathleen A. Hanlon / Lawrence Corey
180. Infections Caused by Arthropod- and Rodent-Borne Viruses — Clarence J. Peters
181. Ebola and Marburg Viruses — Clarence J. Peters

Section 16: Fungal and Algal Infections
182. Diagnosis and Treatment of Fungal Infection — John E. Bennett
183. Histoplasmosis — John E. Bennett
184. Coccidioidomycosis — John E. Bennett
185. Blastomycosis — John E. Bennett
186. Cryptococcosis — John E. Bennett
187. Candidiasis — John E. Bennett
188. Aspergillosis — John E. Bennett
189. Mucormycosis — John E. Bennett
190. Miscellaneous Mycoses and Algal Infections — John E. Bennett
191. Pneumocystis Infection — Peter D. Walzer

Section 17: Protozoal and Helminthic Infections: General Considerations
192. Laboratory Diagnosis of Parasitic Infections — Charles E. Davis
193. Agents Used to Treat Infections Due to Parasites and Pneumocystis — Thomas A. Moore

Section 18: Protozoal Infections
194. Amebiasis and Infection with Free-Living Amebas — Sharon L. Reed
195. Malaria and Babesiosis: Diseases Caused by Red Blood Cell Parasites — Nicholas J. White / Joel G. Breman
196. Leishmaniasis — Barbara L. Herwaldt
197. Trypanosomiasis — Louis V. Kirchhoff
198. Toxoplasma Infection — Lloyd H. Kasper
199. Protozoal Intestinal Infections and Trichomoniasis — Peter F. Weller

Section 19: Helminthic Infections
200. Trichinella and Other Tissue Nematodes — Peter F. Weller
201. Intestinal Nematodes — Peter F. Weller / Thomas B. Nutman
202. Filarial and Related Infections — Thomas B. Nutman / Peter F. Weller
203. Schistosomiasis and Other Trematode Infections — Adel A.F. Mahmoud
204. Cestodes — A. Clinton White, Jr. / Peter F. Weller

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PART SEVEN — BIOTERRORISM AND CLINICAL MEDICINE

205. Microbial Terrorism — H. Clifford Lane / Anthony S. Fauci
206. Chemical Bioterrorism — Charles G. Hurst / Jonathan Newmark / James A. Romano
207. Radiation Bioterrorism — Zelig A. Tochner / Ofer Lehavi / Eli Glatstein

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PART EIGHT — DISORDERS OF THE CARDIOVASCULAR SYSTEM

Section 1: Diagnosis of Cardiovascular Disorders
208. Approach to the Patient with Cardiovascular Disease — Eugene Braunwald
209. Physical Examination of the Cardiovascular System — Robert A. O'Rourke / Eugene Braunwald
210. Electrocardiography — Ary L. Goldberger
211. Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and MRI/CT
Imaging — Rick A. Nishimura / Raymond J. Gibbons / James F. Glockner / A. Jamil Tajik
212. Diagnostic Cardiac Catheterization and Angiography — Donald S. Baim / William Grossman

Section 2: Disorders of Rhythm
213. The Bradyarrhythmias: Disorders of Sinus Node Function and AV Conduction Disturbances AV Conduction Disturbances — Mark E. Josephson / Peter Zimetbaum
214. The Tachyarrhythmias — Mark E. Josephson / Peter Zimetbaum

Section 3: Disorders of the Heart
215. Normal and Abnormal Myocardial Function — Eugene Braunwald
216. Heart Failure and Cor Pulmonale — Eugene Braunwald
217. Cardiac Transplantation and Prolonged Assisted Circulation — Sharon A. Hunt
218. Congenital Heart Disease in the Adult — John S. Child / William F. Friedman
219. Valvular Heart Disease — Eugene Braunwald
220. Pulmonary Hypertension — Stuart Rich
221. Cardiomyopathy and Myocarditis — Joshua Wynne / Eugene Braunwald
222. Pericardial Disease — Eugene Braunwald
223. Cardiac Tumors, Cardiac Manifestations of Systemic Diseases and Traumatic Cardiac Injury — Wilson S. Colucci / Daniel T. Price

Section 4: Vascular Disease
224. The Pathogenesis of Atherosclerosis — Peter Libby
225. Prevention and Treatment of Atherosclerosis — Peter Libby
226. Ischemic Heart Disease — Andrew P. Selwyn / Eugene Braunwald
227. Unstable Angina and Non-ST-Elevation Myocardial Infarction — Christopher P. Cannon / Eugene Braunwald
228. ST-Segment Elevation Myocardial Infarction — Elliott M. Antman / Eugene Braunwald
229. Percutaneous Coronary Revascularization — Donald S. Baim
230. Hypertensive Vascular Disease — Naomi D.L. Fisher / Gordon H. Williams
231. Diseases of the Aorta — Victor J. Dzau / Mark A. Creager
232. Vascular Diseases of the Extremities — Mark A. Creager / Victor J. Dzau

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PART NINE — DISORDERS OF THE RESPIRATORY SYSTEM

Section 1: Diagnosis of Respiratory Disorders
233. Approach to the Patient with Disease of the Respiratory System — Jeffrey M. Drazen/ Steven E. Weinberger
234. Disturbances of Respiratory Function — Steven E. Weinberger/ Jeffrey M. Drazen
235. Diagnostic Procedures in Respiratory Disease — Steven E. Weinberger/ Jeffrey M. Drazen

Section 2: Diseases of the Respiratory System
236. Asthma — E.R. McFadden, Jr.
237. Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia — Joel N. Kline / Gary W. Hunninghake
238. Environmental Lung Diseases — Frank E. Speizer
239. Pneumonia — Thomas J. Marrie / G. Douglas Campbell / David H. Walker / Donald E. Low
240. Bronchiectasis — Steven E Weinberger
241. Cystic Fibrosis — Richard C. Boucher
242. Chronic Obstructive Pulmonary Disease — John J. Reilly / Edwin K. Silverman / Steven D. Shapiro
243. Interstitial Lung Diseases — Talmadge E. King, Jr.
244. Pulmonary Thromboembolism — Samuel Z. Goldhaber
245. Disorders of the Pleura, Mediastinum, Diaphragm, and Chest Wall — Richard W. Light
246. Disorders of Ventilation — Eliot A. Phillipson
247. Sleep Apnea — Eliot A. Phillipson
248. Lung Transplantation — Elbert P. Trulock/ G. Alexander Patterson / Joel D. Cooper

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PART TEN — CRITICAL CARE MEDICINE

Section 1: Respiratory Critical Care
249. Principles of Critical Care Medicine — John P. Kress / Jesse B. Hall
250. Respiratory Failure — Craig Lilly / Edward P. Ingenito / Steven D. Shapiro
251. Acute Respiratory Distress Syndrome — Bruce D. Levy / Steven D. Shapiro
252. Mechanical Ventilatory Support — Edward P. Ingenito / Jeffrey M. Drazen

Section 2: Shock and Cardiac Arrest
253. Approach to the Patient with Shock — Ronald V. Maier
254. Severe Sepsis and Septic Shock — Robert S. Munford
255. Cardiogenic Shock and Pulmonary Edema — Judith S. Hochman / David Ingbar
256. Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death — Robert J. Myerburg / Agustin Castellanos

Section 3: Neurologic Critical Care
257. Acute Confusional States and Coma — Allan H. Ropper
258. Critical Care Neurology — J. Claude Hemphill

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PART ELEVEN — DISORDERS OF THE KIDNEY AND URINARY TRACT

259. Adaptation to Renal Injury — Robert M. Brenner/ Barry M. Brenner
260. Acute Renal Failure — Hugh R. Brady/ Barry M. Brenner
261. Chronic Renal Failure — Karl Skorecki / Jacob Green / Barry M. Brenner
262. Dialysis in the Treatment of Renal Failure — Ajay K. Singh / Barry M. Brenner
263. Transplantation in the Treatment of Renal Failure — Charles B. Carpenter / Edgar L. Milford / Mohamed H. Sayegh
264. Glomerular Diseases — Hugh R. Brady / Yvonne M. O'Meara / Barry M. Brenner
265. Tubular Disorders — John R. Asplin / Fredric L. Coe
266. Tubulointerstitial Diseases of the Kidney — Alan S. L. Yu / Barry M. Brenner
267. Vascular Injury to the Kidney — Kamal F. Badr / Barry M. Brenner
268. Nephrolithiasis — John R. Asplin / Fredric L. Coe / Murray J. Favus
269. Urinary Tract Infections and Pyelonephritis — Walter E. Stamm
270. Urinary Tract Obstruction — Julian L. Seifter / Barry M. Brenner

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PART TWELVE — DISORDERS OF THE GASTROINTESTINAL SYSTEM

Section 1: Disorders of the Alimentary Tract
271. Approach to the Patient with Gastrointestinal Disease — William L. Hasler / Chung Owyang
272. Gastrointestinal Endoscopy — Mark Topazian
273. Diseases of the Esophagus — Raj K. Goyal
274. Peptic Ulcer Disease and Related Disorders — John Del Valle
275. Disorders of Absorption — Henry J. Binder
276. Inflammatory Bowel Disease — Sonia Friedman / Richard S. Blumberg
277. Irritable Bowel Syndrome — Chung Owyang
278. Familial Mediterranean Fever and Other Hereditary Recurrent Fevers — Daniel L. Kastner
279. Common Diseases of the Colon and Anorectum and Mesenteric Vascular Insufficiency — L. Gearhart / Gregory Bulkley
280. Acute Intestinal Obstruction — William Silen
281. Acute Appendicitis and Peritonitis — William Silen

Section 2: Liver and Biliary Tract Disease
282. Approach to the Patient with Liver Disease — Marc Ghany / Jay H. Hoofnagle
283. Evaluation of Liver Function — Daniel S. Pratt / Marshall M. Kaplan
284. The Hyperbilirubinemias — Allan W. Wolkoff
285. Acute Viral Hepatitis — Jules L. Dienstag / Kurt J. Isselbacher
286. Toxic and Drug-Induced Hepatitis — Jules L. Dienstag / Kurt J. Isselbacher
287. Chronic Hepatitis — Jules L. Dienstag / Kurt J. Isselbacher
288. Alcoholic Liver Disease — Mark E. Milliard / Michael F. Sorrell
289. Cirrhosis and Its Complications — Raymond T. Chung / Daniel K. Podolsky
290. Infiltrative, Genetic, and Metabolic Diseases Affecting the Liver — Daniel K Podolsky
291. Liver Transplantation — Jules L. Dienstag
292. Diseases of the Gallbladder and Bile Ducts — Norton J. Greenberger / Gustav Paumgartner

Section 3: Disorders of the Pancreas
293. Approach to the Patient with Pancreatic Disease — Phillip P. Toskes / Norton J. Greenberger
294. Acute and Chronic Pancreatitis — Norton J. Greenberger / Phillip P. Toskes

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PART THIRTEEN — DISORDERS OF THE IMMUNE SYSTEM, CONNECTIVE TISSUE, AND JOINTS

Section 1: The Immune System in Health and Disease
295. Introduction to the Immune System — Barton F. Haynes / Anthony S. Fauci
296. The Major Histocompatibility Gene Complex — Gerald T. Nepom / Joel D. Taurog
297. Primary Immune Deficiency Diseases — Max D. Cooper / Harry W. Schroeder, Jr.

Section 2: Disorders of Immune-Mediated Injury
298. Allergies, Anaphylaxis, and Systemic Mastocytosis — K. Frank Austen
299. Autoimmunity and Autoimmune Diseases — Peter E. Lipsky / Betty Diamond
300. Systemic Lupus Erythematosus — Bevra Hannahs Hahn
301. Rheumatoid Arthritis — Peter E. Lipsky
302. Rheumatic Fever — Edward L. Kaplan
303. Systemic Sclerosis (Scleroderma) and Related Disorders — Bruce C. Gilliland
304. Sjögren's Syndrome — Haralampos M. Moutsopoulos
305. The Spondyloarthritidies — Joel D. Taurog
306. The Vasculitis Syndromes — Michael C. Sneller / Carol A. Langford / Anthony S. Fauci
307. Behçet's Syndrome — Haralampos M. Moutsopoulos
308. Relapsing Polychondritis — Bruce C. Gilliland
309. Sarcoidosis — Ronald G. Crystal
310. Amyloidosis — Jean D. Sipe / Alan S. Cohen

Section 3: Disorders of the Joints and Adjacent Tissues
311. Approach to Articular and Musculoskeletal Disorders — John J. Cush / Peter E. Lipsky
312. Osteoarthritis — Kenneth D. Brandt
313. Gout and Other Crystal Arthropathies — Antonio J. Reginato
314. Infectious Arthritis — Lawrence C. Madoff / Scott J. Thaler / James H. Maguire
315. Fibromyalgia, Arthritis Associated with Systemic Diseases, and Other Arthritides — Bruce C. Gilliland
316. Periarticular Disorders of the Extremities — Bruce C. Gilliland

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PART FOURTEEN — ENDOCRINOLOGY AND METABOLISM

Section 1: Endocrinology
317. Principles of Endocrinology — J. Larry Jameson
318. Disorders of the Anterior Pituitary and Hypothalamus — Shlomo Melmed / J. Larry Jameson
319. Disorders of the Neurohypophysis — Gary L. Robertson
320. Diseases of the Thyroid Gland — J. Larry Jameson / Anthony P. Weetman
321. Disorders of the Adrenal Cortex — Gordon H. Williams / Robert G. Dluhy
322. PheochromocytomavLewis Landsberg / James B. Young
323. Diabetes Mellitus — Alvin C. Powers
324. Hypoglycemia — Philip E. Cryer
325. Disorders of the Testes and Male Reproductive System — Shalendar Bhasin / J. Larry Jameson
326. Disorders of the Ovary and Female Reproductive Tract — Bruce R. Carr / Karen D. Bradshaw
327. The Menopause Transition and Postmenopausal Hormone Therapy — JoAnn E. Manson / Shari S. Bassuk
328. Disorders of Sexual Differentiation — John C. Achermann / J. Larry Jameson
329. Endocrine Tumors of the Gastrointestinal Tract and Pancreas — Robert T. Jensen
330. Disorders Affecting Multiple Endocrine Systems — Steven I. Sherman / Robert F. Gagel

Section 2: Disorders of Bone and Mineral Metabolism
331. Bone and Mineral Metabolism in Health and Disease — F. Richard Bringhurst / Marie B. Demay / Stephen M. Krane / Henry M. Kronenberg
332. Diseases of the Parathyroid Gland and Other Hyper- and Hypocalcemic Disorders — John T. Potts, Jr.
333. Osteoporosis — Robert Lindsay / Felicia Cosman
334. Paget Disease and Other Dysplasias of Bone — Murray J. Favus / Tamara J. Vokes

Section 3: Disorders of Intermediary Metabolism
335. Disorders of Lipoprotein Metabolism — Daniel J. Rader / Helen H. Hobbs
336. Hemochromatosis — Lawrie W. Powell
337. The Porphyrias — Robert J. Desnick
338. Disorders of Purine and Pyrimidine Metabolism — Robert L. Wortmann
339. Wilson Disease — George J. Brewer
340. Lysosomal Storage Diseases — Robert J. Hopkin / Gregory A. Grabowski
341. Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism — Yuan-Tsong Chen
342. Inherited Disorders of Connective Tissue — Darwin J. Prockop / Leena Ala-Kokko
343. Inherited Disorders of Amino Acid Metabolism Presenting in Adults — Nicola Longo
344. Inherited Defects of Membrane Transport — Nicola Longo

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PART FIFTEEN — NEUROLOGIC DISORDERS

Section 1: Diagnosis of Neurologic Disorders
345. Neurobiology of Disease — Stephen L. Hauser / M. Flint Beal
346. Approach to the Patient with Neurologic Disease — Joseph B. Martin / Daniel H. Lowenstein / Stephen L. Hauser
347. Neuroimaging in Neurologic Disorders — William P. Dillon

Section 2: Diseases of the Central Nervous System
348. Seizures and Epilepsy — Daniel H. Lowenstein
349. Cerebrovascular Diseases — Wade S. Smith / S. Claiborne Johnston / J. Donald Easton
350. Alzeimer’s Disease and Other Dementias — Thomas D. Bird / Bruce L. Miller
351. Parkinson's Disease and Other Movement Disorders — Mahlon R. DeLong / Jorge L. Juncos
352. Ataxic Disorders — Roger N. Rosenberg
353. Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases — Robert H. Brown, Jr.
354. Disorders of the Autonomic Nervous System — Phillip A. Low / John W. Engstrom
355. Trigeminal Neuralgia, Bell's Palsy, and Other Cranial Nerve Disorders — M. Flint Beal / Stephen L. Hauser
356. Diseases of the Spinal Cord — Stephen L. Hauser / Allan H. Ropper
357. Concussion and Other Head Injuries — Allan H. Ropper
358. Primary and Metastatic Tumors of the Nervous System — Stephen M. Sagar / Mark A. Israel
359. Multiple Sclerosis and Other Demyelinating Diseases — Stephen L. Hauser / Douglas S. Goode
360. Meningitis, Encephalitis, Brain Abscess, and Empyema — Karen L. Roos / Kenneth L. Tyler
361. Chronic and Recurrent MeningitisWalter J. Koroshetz / Morton N. Swartz
362. Prion Diseases — Stanley B. Prusiner / Bruce Miller

Section 3: Disorders of Nerves and Muscles
363. Approach to the Patient with Peripheral Neuropathy — Arthur K. Asbury
364. Charcot-Marie-Tooth Disease and Other Inherited Neuropathies — Philip F. Chance / Thomas D. Bird
365. Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies — Stephen L. Hauser / Arthur K. Asbury
366. Myasthenia Gravis and Other Diseases of the Neuromuscular Junction — Daniel B. Drachman
367. Approach to the Patient with Muscle Disease — Jerry R. Mendell
368. Muscular Dystrophies and Other Muscle Diseases — Robert H. Brown, Jr. / Jerry R. Mendell
369. Polymyositis, Dermatomyositis, and Inclusion Body Myositis — Marinos C. Dalakas

Section 4: Chronic Fatigue Syndrome
370. Chronic Fatigue Syndrome — Stephen E. Straus

Section 5: Psychiatric Disorders
371. Mental Disorders — Victor I. Reus

Section 6: Alcoholism and Drug Dependency
372. Alcohol and Alcoholism — Marc A. Schuckit
373. Opioid Drug Abuse and Dependence — Marc A. Schuckit / David S. Segal
374. Cocaine and Other Commonly Abused Drugs — Jack H. Mendelson / Nancy K. Mello
375. Nicotine Addiction — David M. Burns

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PART SIXTEEN — POISONING, DRUG OVERDOSE, AND ENVENOMATION

376. Heavy Metal Poisoning — Howard Hu
377. Poisoning and Drug Overdosage — Christopher H. Linden / Michael J. Burns
378. Disorders Caused by Reptile Bites and Marine Animal Exposures — Paul S. Auerbach / Robert L. Norris
379. Ectoparasite Infestations and Arthropod Bites and Stings — James H. Maguire / Richard J. Pollack / Andrew Spielman

380. Appendices: Laboratory Values of Clinical Importance — Alexander Kratz / Patrick M. Sluss / James L. Januzzi, Jr. / Kent B. Lewandrowski