CONTENTS

SECTION I
GENERAL PRINCIPLES : 1

1. Pharmacokinetics and Pharmacodynamics: The Dynamics of Drug Absorption, Distribution, Action, and Elimination : 1
   Iain L. O. Buxton
2. Membrane Transporters and Drug Response : 41
   Kathleen M. Giacomini and Yuichi Sugiyama
3. Drug Metabolism : 71
   Frank J. Gonzalez and Robert H. Tukey
4. Pharmacogenetics : 93
   Mary V. Relling and Kathleen M. Giacomini
5. The Science of Drug Therapy : 117
   John A. Oates

SECTION II
DRUGS ACTING AT SYNAPTIC AND NEUROEFFECTOR JUNCTIONAL SITES : 137

1. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems : 137
   Thomas C. Westfall and David P. Westfall
2. Muscarinic Receptor Agonists and Antagonists : 183
   Joan Heller Brown and Palmer Taylor
3. Anticholinesterase Agents : 201
   Palmer Taylor
4. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia : 217
   Palmer Taylor
5. Adrenergic Agonists and Antagonists : 237
   Thomas C. Westfall and David P. Westfall
6. 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists : 297
   Elaine Sanders-Bush and Steven E. Mayer

SECTION III
DRUGS ACTING ON THE CENTRAL NERVOUS SYSTEM : 317

1. Neurotransmission and the Central Nervous System : 317
   Floyd E. Bloom
2. General Anesthetics : 341
   Alex S. Evers, C. Michael Crowder, and Jeffrey R. Balser
3. Local Anesthetics : 369
   William A. Catterall and Ken Mackie
4. Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium : 387
   Brett A. Simon, Eric J. Moody, and Roger A. Johns
5. Hypnotics and Sedatives : 401
   Dennis S. Charney, S. John Mihic, and R. Adron Harris
6. Drug Therapy of Depression and Anxiety Disorders : 429
   Ross J. Baldessarini
7. Pharmacotherapy of Psychosis and Mania : 461
   Ross J. Baldessarini and Frank I. Tarazi
8. Pharmacotherapy of the Epilepsies : 501
   James O. McNamara
9. Treatment of Central Nervous System Degenerative Disorders : 527
   David G. Standaert and Anne B. Young
10. Opioid Analgesics : 547
    Howard B. Gutstein and Huda Akil
11. Ethanol : 591
    Michael F. Fleming, S. John Mihic, and R. Adron Harris
12. Drug Addiction and Drug Abuse : 607
    Charles P. O'Brien

SECTION IV
AUTACOIDS: DRUG THERAPY OF INFLAMMATION : 629

1. Histamine, Bradykinin, and Their Antagonists : 629
   Randal A. Skidgel and Ervin G. Erdös
2. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor : 653
   Emer M. Smyth, Anne Burke, and Garret A. FitzGerald
3. Analgesic-Antipyretic Agents; Pharmacotherapy of Gout : 671
   Anne Burke, Emer M. Smyth, and Garret A. FitzGerald
4. Pharmacotherapy of Asthma : 717
   Bradley J. Undem

SECTION V
DRUGS AFFECTING RENAL AND CARDIOVASCULAR FUNCTION : 737

1. Diuretics : 737
   Edwin K. Jackson
2. Vasopressin and Other Agents Affecting the Renal Conservation of Water : 771
   Edwin K. Jackson
3. Renin and Angiotensin : 789
   Edwin K. Jackson
4. Treatment of Myocardial Ischemia : 823
   Thomas Michel
5. Therapy of Hypertension : 845
   Brian B. Hoffman
6. Pharmacotherapy of Congestive Heart Failure : 869
   Thomas P. Rocco and James C. Fang
7. Antiarrhythmic Drugs : 899
   Dan M. Roden
8. Drug Therapy for Hypercholesterolemia and Dyslipidemia : 933
   Robert W. Mahley and Thomas P. Bersot

SECTION VI
DRUGS AFFECTING GASTROINTESTINAL FUNCTION : 967

1. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease : 967
   Willemijntje A. Hoogerwerf and Pankaj Jay Pasricha
2. Treatment of Disorders of Bowel Motility and Water Flux; Antiemetics; Agents Used in Biliary and Pancreatic Disease : 983
   Pankaj Jay Pasricha
3. Pharmacotherapy of Inflammatory Bowel Disease : 1009
   Joseph H. Sellin and Pankaj Jay Pasricha

SECTION VII
CHEMOTHERAPY OF PARASITIC INFECTIONS : 1021

1. Chemotherapy of Protozoal Infections: Malaria : 1021
   Theresa A. Shapiro and Daniel E. Goldberg
2. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections : 1049
   Margaret A. Phillips and Samuel L. Stanley, Jr.
3. Chemotherapy of Helminth Infections : 1073
   Alex Loukas and Peter J. Hotez

SECTION VIII
CHEMOTHERAPY OF MICROBIAL DISEASES : 1095

1. General Considerations of Antimicrobial Therapy : 1095
   Henry F. Chambers
2. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections : 1111
   William A. Petri, Jr.
3. Penicillins, Cephalosporins, and Other ß-Lactam Antibiotics : 1127
   William A. Petri, Jr.
4. Aminoglycosides : 1155
   Henry F. Chambers
5. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents : 1173
   Henry F. Chambers
6. Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy : 1203
   William A. Petri, Jr.
7. Antifungal Agents : 1225
   John E. Bennett
8. Antiviral Agents (Nonretroviral) : 1243
   Frederick G. Hayden
9. Antiretroviral Agents and Treatment of HIV Infection : 1273
   Charles Flexner

SECTION IX
CHEMOTHERAPY OF NEOPLASTIC DISEASES : 1315

1. Antineoplastic Agents : 1315
   Bruce A. Chabner, Philip C. Amrein, Brian Druker, M. Dror Michaelson, Constantine S. Mitsiades, Paul E. Goss, David P. Ryan, Sumant Ramachandra, Paul G. Richardson, Jeffrey G. Supko, and Wyndham H. Wilson

SECTION X
IMMUNOMODULATORS : 1405

1. Immunosuppressants, Tolerogens, and Immunostimulants : 1405
   Alan M. Krensky, Flavio Vincenti, and William M. Bennett

SECTION XI
DRUGS ACTING ON THE BLOOD AND THE BLOOD-FORMING ORGANS : 1433

1. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins : 1433
   Kenneth Kaushansky and Thomas J. Kipps
2. Blood Coagulation and Anticoagulant, Thrombolytic, and Antiplatelet Drugs : 1467
   Philip W. Majerus and Douglas M. Tollefsen

SECTION XII
HORMONES AND HORMONE ANTAGONISTS : 1489

1. Pituitary Hormones and Their Hypothalamic Releasing Factors : 1489
   Keith L. Parker and Bernard P. Schimmer
2. Thyroid and Antithyroid Drugs : 1511
   Alan P. Farwell and Lewis E. Braverman
3. Estrogens and Progestins : 1541
   David S. Loose and George M. Stancel
4. Androgens : 1573
   Peter J. Snyder
5. Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones : 1587
   Bernard P. Schimmer and Keith L. Parker
6. Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas : 1613
   Stephen N. Davis
7. Agents Affecting Mineral Ion Homeostasis and Bone Turnover : 1647
   Peter A. Friedman

SECTION XIII
DERMATOLOGY : 1679

1. Dermatological Pharmacology : 1679
   Lindy P. Fox, Hans F. Merk, and David R. Bickers

SECTION XIV
OPHTHALMOLOGY : 1707

1. Ocular Pharmacology : 1707
   Jeffrey D. Henderer and Christopher J. Rapuano

SECTION XV
TOXICOLOGY : 1739

1. Principles of Toxicology and Treatment of Poisoning : 1739
   Curtis D. Klaassen
2. Heavy Metals and Heavy-Metal Antagonists : 1753
   Curtis D. Klaassen

APPENDICES

1. Principles of Prescription Order Writing and Patient Compliance : 1777
   Iain L. O. Buxton
2. Design and Optimization of Dosage Regimens; Pharmacokinetic Data : 1787
   Kenneth E. Thummel, Danny D. Shen, Nina Isoherranen, and Helen E. Smith

INDEX

Index : 1889

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